Table 1.

Pancreas cancer cell lines characteristics and their dasatinib IC₅₀

Cell Line	Derivation	Genetic background	IC50 (nmol/L)
MiaPaca2	Primary	Mutant K-ras, mutant p53, wt smad4	51.28
PANC1	Primary	Mutant K-ras, mutant p53, wt smad4	45.68
AsPC1	Metastasis (ascites)	Mutant K-ras, wt p53, wt smad4	44.97
CEPAC1	Metastasis (liver)	Mutant K-ras, wt p53, mutant smad4	24.99
Capan1	Metastasis (liver)	Mutant K-ras, ND p53, mutant smad4	9.604
SW1990	Metastasis (spleen)	Mutant K-ras, wt p53, ND smad4	5.106
Capan2	Primary	Mutant K-ras, wt p53, wt smad4	4.872
HPAC	Primary	Mutant K-ras, wt p53, wt smad4	2.791
BxPC3	Primary	Wt K-ras, mutant p53, mutant smad4	2.809

WT: wild type; ND: not determined