Table 1.
Effects of highly active anti retroviral therapy (HAART) initiation or interruption on viral load, CD4 counts, CD38hi CD8+ T cells and CCR5 density on the surface of DR− CD4+ T cells in eleven and six HIV-1-infected patients, respectively. For HAART initiation and interruption, months represent time from initiation of therapy and time from cessation of therapy, respectively
| Months | |||
|---|---|---|---|
| 0 | 6 | P-value | |
| HAART initiation, mean (95% CI) | |||
| Viral load, HIV-1 RNA copies/ml | 91 042 (28 599–153 484) | 53 (38–68) | 0·009 |
| CD4 counts, cells/μl | 281 (168–394) | 472 (364–581) | < 10−4 |
| CD38hi CD8+ T cells,% | 38 (21–55) | 10 (6–15) | 0·003 |
| CCR5 density, molecules/cell | 5762 (3956–7567) | 5476 (3645–7308) | 0·541 |
| HAART interruption, mean (95% CI) | |||
| Viral load, HIV-1 RNA copies/ml | 238 (0–713) | 80 583 (5720–155 447) | 0·040 |
| CD4 counts, cells/μl | 677 (425–928) | 473 (317–629) | 0·015 |
| CD38hi CD8+ T cells, % | 4 (0–8) | 18 (7–29) | 0·011 |
| CCR5 density, molecules/cell | 5281 (3723–6839) | 5903 (4246–7540) | 0·366 |