Figure 1.

Comparison of the effects of acute and repeated administration of the FAAH inhibitor URB597 (0.3 mg·kg⁻¹) on carrageenan-induced pain behaviour. (A) Acute URB597 attenuated carrageenan-induced changes in weight bearing. Data were analysed using two-way anova followed by Bonferroni's post hoc test, *P < 0.05, ***P < 0.001. (B) Inhibitory effects of acute URB597 at 120 min after carrageenan injection were significantly blocked by co-administration of the PPARα antagonist GW6471 (10 mg·kg⁻¹) with URB597 and by co-administration of the CB₁ receptor antagonist AM251 (5 mg·kg⁻¹). Data were analysed using one-way anova with Bonferroni's post hoc test, *P < 0.05, **P < 0.01. (C) Repeated administration of URB597 did not alter carrageenan-induced changes in weight bearing. Data shown are differences in weight bearing between contralateral and ipsilateral hind paw and are expressed as mean ± SEM.