Table 2.

Comparison of the effects of acute and repeated administration of URB597 (0.3 mg·kg⁻¹) on levels of AEA, PEA, OEA and 2-AG in the ipsilateral spinal cord of carrageenan-treated rats

		Relative levels of endocannabinoids and related NAEs (% control)
		AEA	PEA	OEA	2-AG
Spinal Cord	Acute URB597	213 ± 31*	278 ± 62	337 ± 72*	84 ± 32
	Repeated URB597	123 ± 22	149 ± 17	158 ± 26	112 ± 17

Data are expressed as a percentage of the mean level in the ipsilateral spinal cord of carrageenan-treated rats receiving either acute or repeated administration of vehicle (n= 9–13 rats per group). Statistical comparisons between the effects of acute and repeated administration of URB597 was carried out using a Mann–Whitney non-parametric test (*P < 0.05)