Table 1.
Activity | Distribution | CRC Classification | ||||||
---|---|---|---|---|---|---|---|---|
1a | 1b | unqualified | 2a | 2b | unqualified | 3 | ||
Activation | #Samples Screened | 0 | 1 | 0 | 2 | 12 | 0 | 0 |
Inhibition | #Samples Screened | 5,306 | 2,191 | 123 | 5,772 | 19,938 | 493 | 10,062 |
Library (%) | 1.46 | 0.60 | 0.03 | 1.58 | 5.48 | 0.14 | 2.76 |
Activators composed <0.004% of the activity. Unqualified, CRCs of lower quality in each of the class 1 or 2 CRC datasets using a <50% efficacy cut-off. The total # of inactive compounds was 320,205 (87.94%). Supported by Figure S1 and Table S2.