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. Author manuscript; available in PMC: 2013 Aug 24.
Published in final edited form as: Chem Biol. 2012 Aug 24;19(8):1060–1072. doi: 10.1016/j.chembiol.2012.07.015

Table 1.

Distribution of Inhibition Activity

Activity Distribution CRC Classification
1a 1b unqualified 2a 2b unqualified 3
Activation #Samples Screened 0 1 0 2 12 0 0
Inhibition #Samples Screened 5,306 2,191 123 5,772 19,938 493 10,062
Library (%) 1.46 0.60 0.03 1.58 5.48 0.14 2.76

Activators composed <0.004% of the activity. Unqualified, CRCs of lower quality in each of the class 1 or 2 CRC datasets using a <50% efficacy cut-off. The total # of inactive compounds was 320,205 (87.94%). Supported by Figure S1 and Table S2.