TABLE 3.
Risk factor analysis for postoperative CSF leak using logistic regression analysis*
| Variable | Total No. of Patients | Postoperative CSF Leak (n = 13)
|
||
|---|---|---|---|---|
| No. (%) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | ||
| age in yrs, continuous | 0.94 (0.89–0.98) | 0.93 (0.88–0.98) | ||
| sex | ||||
| female | 50 | 10 (20) | 1.0 | — |
| male | 46 | 3 (6.5) | 0.28 (0.05–1.20) | — |
| BMI in kg/m2, continuous† | 1.47 (1.05–2.01) | 1.61 (1.10–2.29) | ||
| mass vol in cm3, continuous sella/suprasellar remnant | 0.94 (0.84–1.06) | — | ||
| no | 49 | 9 (18.4) | 1.0 | — |
| yes | 47 | 4 (7.8) | 0.42 (0.09–1.64) | — |
| cavernous remnant | ||||
| no | 74 | 11 (14.9) | 1.0 | — |
| yes | 22 | 2 (9.1) | 0.58 (0.06–2.99) | — |
| sphenoid packing | ||||
| no | 70 | 4 (5.7) | 1.0 | — |
| yes | 26 | 7 (26.9) | 3.86 (0.98–15.8) | — |
| intraop lumbar drain/puncture | ||||
| no | 0 | 12 (12.6) | 1.0 | — |
| yes | 1 | 1 (100) | 6.39 (0.16–infinity) | — |
| repeat transsphenoidal surgery | ||||
| no | 89 | 11 (12.4) | 1.0 | — |
| yes | 7 | 2 (28.6) | 2.80 (0.24–19.88) | — |
| intraop leak | ||||
| no | 55 | 4 (7.3) | 1.0 | 1.0 |
| yes | 41 | 9 (21.9) | 3.54 (0.89–17.06) | 5.66 (1.10–47.95) |
*
Unadjusted odds ratios were determined with univariate logistic regression analysis and adjusted odds ratios were determined using multivariate logistic regression analysis.
†
For every 5-kg/m2 increase in BMI.