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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2011 Dec 20;20(3):1337–1345. doi: 10.1016/j.bmc.2011.12.013

Scheme 3.

Scheme 3

Synthesis of radiolabeling precursor 16. Reagents and conditions: (a) HCO2H; (b) 4-(1-piperidinyl) piperidine, HOBt, EDC·HCl, CH2Cl2, rt, 18 h; (c) H2, Pd/C 5%, MeOH, 18 h; (d) Na2SO4 anhydrous, CH2Cl2; (d′) oxalyl chloride, DMF cat., CH2Cl2; (e) NEt3, CH2Cl2, 0 °C to rt, 1 h.