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Vasopressin receptor affinity and PAMPA-BBB results for potential SRX246 based PET and SPECT ligands
| Compound | hV1a Ki (nM) | hV1b Ki (nM) | hV2 Ki (nM) | cLogP | Pe (10−6 cm s−1) | Predicted CNS penetration |
|---|---|---|---|---|---|---|
| 11a | 1.1 | >1000 | >1000 | 5.62 | 2.2 | CNS± |
| 11b | 0.61 | 1154 | >10,000 | 4.42 | 5.3 | CNS+ |
| 11c | 0.63 | 1300 | >10,000 | 4.75 | 4.5 | CNS+ |
