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. Author manuscript; available in PMC: 2013 Dec 29.
Published in final edited form as: Cancer Lett. 2012 Aug 1;326(1):88–95. doi: 10.1016/j.canlet.2012.07.028

Fig. 2. Silibinin feeding provided marginal hepatoprotective effects in male and female DEN-initiated mice, and exacerbated carcinogenesis when combined with ethanol.

Fig. 2

(a) Representative images of livers resected from male and female DEN-initiated mice (48 weeks) maintained on dietary silibinin alone or in combination with ethanol feeding. (b) Liver injury was blind-scored from representative H and E (c) and Picosirius red sections (Suppl. Fig. 2) (2 lobes/mouse, 5 fields/lobe) from each experimental group to generate a total liver injury score (TLIS) (d) Serum alanine aminotransferase (ALT) activity was measured. (S; dietary silibinin, D; DEN-initiated, DS; DEN-initiated/dietary silibinin, DES; DEN-initiated/dietary silibinin/EtOH). n≥5 animals/group, p<.05 S vs D, DS and DES in male and female groups, # p<.05 male vs female, § p<.05 DES vs D and DS.