Table 1.

The effects of alanine-substituted analogs on adult and larval gut are reported as mean values calculated as percent inhibition relative to the effect of DMS. The symbol † indicates p ≤0.00001.

			% Inhibition (gut)
			Adult	p value	Larval	p value
DMS		TDVDHVFLRFamide	100		100
[A1]DMS		ADVDHVFLRFamide	100	1	95	0.6
[A2]DMS		TAVDHVFLRFamide	100	1	32	0.002
[A3]DMS		TDADHVFLRFamide	100	1	26	0.00008
[A4]DMS		TDVAHVFLRFamide	91	1	10	0.00002
[A5]DMS		TDVDAVFLRFamide	78	0.01	14	†
[A6]DMS		TDVDHAFLRFamide	100	1	91	0.5
[A7]DMS		TDVDHVALRFamide	70	0.008	10	†
[A8]DMS		TDVDHVFARFamide	14	†	42	0.0005
[A9]DMS		TDVDHVFLAFamide	100	1	74	0.1
[A10]DMS		TDVDHVFLRAamide	90	0.08	26	0.0002
DMS-OH		TDVDHVFLRF-OH	71	0.002	19	†
Saline			23	†	8	†