. 2012 Aug 31;3:346. doi: 10.3389/fphys.2012.00346

Table 2.

Ion channel current and gating properties in hiPS-CM and human cardiomyocytes.

	Cell type	Peak current (pA/pF)	V_1/2 act (mV)	k act	V_1/2 inact (mV)	k inact	Exp. conditions	Reference
I_Na	iPS-CM	−216.7 ± 18.7	−34.1	5.9	−72.1	−5.7	35–37°C wc, LJP: nk	Ma et al., 2011
	iPS-CM	~280 (Figure 8C)	~ −42 (Figure 8D)				37°C, pp LJP: nc	Davis et al., 2012
	hESC-CM	−72 ± 21	−34	5.7	−78	−4.6	20°C, wc LJP: nk	Jonsson et al., 2012
	VM	−20.2 ± 2.2	−42.4 ± 3.0	6.3 ± 0.5	−100 ± 2.1	−6.3 ± 0.5	17°C, wc LJP: nk	Sakakibara et al., 1993
I_Ca,L	iPS-CM	−17.1 ± 1.7	−14.9	6.6	−29.1	−4.9	35–37°C wc, LJP: nk	Ma et al., 2011
	iPS-CM	−3.3	~ −45 (Figure 2E)				25°C, wc LJP: nk	Yazawa et al., 2011
	hESC-CM	−4.3 ± 0.6	−12	5.5			37°C, wc LJP: nk	Jonsson et al., 2012
	VM	−10.2 ± 0.6	−4.7 ± 0.7	3.7 ± 0.3	−19.3 ± 1.2	−3.45 ± 0.6	37°C, wc LJP: nk	Magyar et al., 2000
	VM	−3.8 ± 0.5	−4.2 ± 0.8	7 ± 0.3	−23.5 ± 1.4	−5.5 ± 1.4	21–23°C wc, LJP: nk	Mewes and Ravens, 1994
	AM	−2.2 ± 0.3	−12.1 ± 1.3	5.8 ± 0.4	−26.8 ± 1.3	−5.7 ± 0.2	21–23°C wc, LJP: nk	Mewes and Ravens, 1994
I_to1	iPS-CM	~2.4 (Figure 6D)					35–37°C wc, LJP: nk	Ma et al., 2011
	iPS-CM	~30 (Suppl. Figure 10A)					35°C, wc LJP: nk	Moretti et al., 2010
	hESC-CM	6.0 ± 0.9					37°C, wc LJP: nk	Sartiani et al., 2007
	VM endo	~5 (Figure 2B)	29.1 ± 1.2	12.9 ± 1.1	−17.6 ± 1.0	−8.9 ± 0.9	35°C, wc LJP: nk	Nabäuer et al., 1996
	VM epi	~16 (Figure 2A)	32.0 ± 1.11	14.9 ± 0.8	−9.5 ± 0.38	−5.1 ± 0.4	35°C, wc LJP: nk	Nabäuer et al., 1996
	VM endo	2.3 ± 0.3	23.1 ± 4.2	12.9 ± 0.8	−25.3 ± 3.0	−4.7 ± 0.8	20–22°C wc, LJP: nk	Wettwer et al., 1994
	VM epi	7.9 ± 0.7	15.4 ± 0.7	9.7 ± 1.6	−31.9 ± 1.5	−4.6 ± 0.2	20–22°C wc, LJP: nk	Wettwer et al., 1994
I_Kr	iPS-CM	0.95 ± 0.02	−22.7	4.9			35–37°C wc, LJP: nk	Ma et al., 2011
	iPS-CM	~1.9 (Figure 4A)					35°C, wc LJP: nk	Moretti et al., 2010
	iPS-CM	~1.9 (Figure 5C)					36°C, pp LJP: nk	Lahti et al., 2012
	iPS-CM	~0.55 (Figure 3D)					32°C, wc LJP: nk	Itzhaki et al., 2011a
	hESC-CM	−11.5 ± 1.8					37°C, wc LJP: nk	Jonsson et al., 2012
	VM	~0.25 (Figure 1C)	−5.74	5.63			37°C, wc LJP: nk	Iost et al., 1998
	VM	0.31 ± 0.02					37°C, wc LJP: nk	Magyar et al., 2000
I_Ks	iPS-CM	0.31 ± 0.09					35–37°C wc, LJP: nk	Ma et al., 2011
	iPS-CM	~2.5 (Figure 4A)					35°C, wc LJP: nk	Moretti et al., 2010
	hESC-CM	0.65 ± 0.12					37°C, wc LJP: nk	Jonsson et al., 2012
	VM	0.18					37°C, wc LJP: nk	Virag et al., 2001
I_K1	iPS-CM	~ −3.8 (Figure 6C)					35–37°C wc, LJP: nk	Ma et al., 2011
	hESC-CM	−2.67 ± 0.3					37°C, wc LJP: nk	Jonsson et al., 2012
	VM	~ −10 (Figure 3B)					37°C, wc LJP: nk	Magyar et al., 2000
I_f	iPS-CM	−4.1 ± 0.3	−84.6	8.8			35–37°C wc, LJP: nk	Ma et al., 2011
	hESC-CM	−10 ± 1.1	−74	4.5			37°C, wc LJP: nk	Jonsson et al., 2012
	VM	−1.18 ± 0.21	−111 ± 0.06				22°C, wc LJP: nk	Hoppe et al., 1998
	SAN	~ −8.0 (Figure 3B)	−96.9 ± 2.7	8.8 ± 0.5			36°C, wc LJP: corr	Verkerk et al., 2007

VM, native human ventricular myocyte; AM, native human atrial myocyte; endo, endocardial; epi, epicardial; SAN; native sinoatrial node myocyte; ~, estimated from figure. I_Na, Na⁺ current; I_Ca,L, L-type Ca²⁺ current; I_to1, Transient outward current type 1; I_Kr, rapid compontent of the delayed rectifier K⁺ current; I_Ks, slow component of the delayed rectifier K⁺ current; I_K1, inward rectifier K⁺ current; I_f, funny current; V_1/2 act, potential of half maximal activation; k act, slope factor of activation curve; V_1/2 inact, potential of half maximal inactivation; k inact, slope factor of inactivation curve hESC-CM; V, hESC-CM of ventricular-like phenotype; wc, whole cell patch-clamp configuration; ljp: corr, corrected for liquid junction potential; ljp: nk, not known if corrected for liquid junction potential, ljp: nc, not corrected for liquid junction potential.