Figure 7.

MRI of tumors in vivo. (A) Representative subsets of T₂-weighted MRI and (B) changes in signal intensity before and after injection of saline solution, USPIOs, PLDUs, and M-PLDUs.

Notes: MRI of the tumors was performed with a 3T MR scanner (Siemens Trio) using a surface coil with T₂-weighted spin echo sequence (TR = 2500 ms; TE = 30 ms; FOV = 40 × 40 mm²; matrix = 512 × 512; slice thickness = 0.8 mm). Quantitative information in signal intensities was inferred by ImageJ software (n = 4 in each group; *P < 0.05, **P < 0.01).

Abbreviation: USPIOs, ultrasmall superparamagnetic iron oxides.