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. 2011 Jun 15;22(3):584–594. doi: 10.1093/cercor/bhr131

Figure 5.

Figure 5.

Activation of mGluR II decreases mEPSC frequency with no effects on mEPSC amplitudes. (A) mEPSCs recorded from a layer III pyramidal neuron in the presence of TTX (1 μM) before and after the application of LY354740 (3 μM). (B) Time course of the mEPSC frequency averaged from 6 cells. Numbers of mEPSCs at each min were normalized to that of mEPSCs in the 5 min prior to the application of LY354740. (C) Cumulative frequency distribution from a layer III pyramidal neuron before (solid) and after (dotted) the application of LY354740. Note that LY354740 increased the intervals of the mEPSC (decreased mEPSC frequency, P = 0.03, Kolmogorov–Smirnov test). (D) Cumulative amplitude distribution from the same cell before (solid) and after (dotted) the application of LY354740 (P = 0.67, Kolmogorov–Smirnov test). (E) Summarized data for LY354740-induced attenuation of mEPSC frequency (n = 6). (F) LY354740 failed to alter significantly mEPSC amplitudes (n = 6).