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The Journal of Headache and Pain logoLink to The Journal of Headache and Pain
. 2010 Jun 2;11(5):437–440. doi: 10.1007/s10194-010-0226-z

Intracranial hypotension and PRES: case report

Silvia Pugliese 1,, V Finocchi 1, M L Borgia 2, C Nania 2, B Della Vella 2, A Pierallini 3, A Bozzao 1
PMCID: PMC3452280  PMID: 20517704

Abstract

We report a case of a woman presenting, 7 days after epidural analgesia for a caesarean section, to the emergency room for a worsening of the headache and tonico-clonic seizures. MRI showed alterations suggestive of the presence of intracranial hypotension (IH) as well as evidence of posterior reversible encephalopathy syndrome (PRES). She was treated with a blood patch which leads to the prompt regression of the clinical symptoms and follow-up MRI, after 15 days, showed complete resolution of radiological alterations. The possible pathogenetic relationship between IH, secondary to the inadvertent dural puncture, and PRES is discussed. We suggest that venous stagnation and hydrostatic edema, secondary to intracranial hypotension, probably played a crucial role in the pathogenesis of PRES.

Keywords: Intracranial hypotension, PRES, MRI, Epidural analgesia, Headache

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Conflict of interest

None.

References

  • 1.Mokri B. Headaches caused by decreased intracranial pressure: diagnosis and management. Curr Opin Neurol. 2003;16:319–326. doi: 10.1097/01.wco.0000073933.19076.c0. [DOI] [PubMed] [Google Scholar]
  • 2.Cesur M, Alici HA, Erdem AF, Silbir F, Celik M. Decreased incidence of headache after unintentional dural puncture in patients with cesarean delivery administered with postoperative epidural analgesia. J Anesth. 2009;23:31–35. doi: 10.1007/s00540-008-0690-7. [DOI] [PubMed] [Google Scholar]
  • 3.Sell J, Rupp FW, Orrison W. Iatrogenically induced intracranial hypotension syndrome. AJR. 1995;165:1513–1515. doi: 10.2214/ajr.165.6.7484598. [DOI] [PubMed] [Google Scholar]
  • 4.Berroir S, Loisel B, Ducros A, et al. Early epidural blood patch in spontaneous intracranial hypotension. Neurology. 2004;63:1950–1951. doi: 10.1212/01.wnl.0000144339.34733.e9. [DOI] [PubMed] [Google Scholar]
  • 5.Ay H, Buonanno F, Schaefer P, et al. Posterior leukoencephalopathy without severe hypertension. Utility of diffusion-weighted MRI. Neurology. 1998;51:1369–1376. doi: 10.1212/wnl.51.5.1369. [DOI] [PubMed] [Google Scholar]
  • 6.Finocchi V, Bozzao A, Bonamini M, Ferrante M, Romano A, Colonnese C, Fantozzi LM. Magnetic resonance imaging in posterior reversible encephalopathy syndrome: report of three cases and review of literature. Arch Gynecol Obstet. 2005;271:79–85. doi: 10.1007/s00404-004-0622-1. [DOI] [PubMed] [Google Scholar]
  • 7.Hinchey J, Chaves C, Appignani B, et al. A reversible posterior encephalopathy syndrome. N Engl J Med. 1996;334:494–500. doi: 10.1056/NEJM199602223340803. [DOI] [PubMed] [Google Scholar]
  • 8.Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain. 2007;130:3091–3101. doi: 10.1093/brain/awm256. [DOI] [PubMed] [Google Scholar]
  • 9.Mokri B. The Monro–Kellie hypothesis. Applications in CSF volume depletion. Neurology. 2001;56:1746–1748. doi: 10.1212/wnl.56.12.1746. [DOI] [PubMed] [Google Scholar]
  • 10.Savoiardo M, Minati L, Farina L, Simone T, Aquino D, Mea E, Filippini G, Bussone G, Chiapparini L. Spontaneous intracranial hypotension with deep brain swelling. Brain. 2007;130:1884–1893. doi: 10.1093/brain/awm101. [DOI] [PubMed] [Google Scholar]
  • 11.Savoiardo M, Armenise S, Spagnolo P, Simone T, Mandelli ML, Marcone A, et al. Dural sinus thrombosis in spontaneous intracranial hypotension: hypothesis on possible mechanism. J Neurol. 2006;253:1197–1202. doi: 10.1007/s00415-006-0194-z. [DOI] [PubMed] [Google Scholar]
  • 12.Hinchey J, Chaves C, Appignani B, et al. A reversible posterior encephalopathy syndrome. N Engl J Med. 1996;334:494–500. doi: 10.1056/NEJM199602223340803. [DOI] [PubMed] [Google Scholar]

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