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Reversible posterior leukoencephalopathy syndrome (RPLS): This 47-year-old woman had an 18-month history of a corpus callosum glioblastoma that progressed despite radiation with temozolomide, temsirolimus with sorafenib, and then BCNU (Carmustine). She presented 3 weeks after starting bevacizumab with headache, seizures, unresponsiveness, and blood pressure of 160/100 mm Hg. FLAIR-weighted MRI sequences 2 weeks before (A and B) and 3 weeks after her first dose of bevacizumab (C and D).
