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Indian Journal of Clinical Biochemistry logoLink to Indian Journal of Clinical Biochemistry
. 2009 Jul 9;24(2):155–158. doi: 10.1007/s12291-009-0028-8

Clinicopathological spectrum of non-alcoholic fatty liver disease among patients in Kerala

Subir Kumar Das 2,3,✉, Sukhes Mukherjee 2, Gaurav Pandey 1, V Balakrishnan 1, D M Vasudevan 2
PMCID: PMC3453229  PMID: 23105825

Abstract

Non-alcoholic fatty liver disease and its more aggressive form, non-alcoholic steatohepatitis are entities that are becoming more and more interesting to the medical community in general. A total of 93 Non-alcoholic fatty liver disease patients (64 male and 29 female) within the age range between 28 to 63 years were studied. All of them showed elevated alanine aminotransferase level (104.07 ± 56.04). Aspartate aminotransferase level (58.13 ± 31.96) was elevated more than its normal level in 82% cases and AST to ALT ratio was found 0.59 ± 0.26. Predisposing factors were diabetes mellitus (37%), obesity (13%) and hyperlipidemia (41%). In addition, 32% of the subjects were overweight.18% of the patients had elevated serum bilirubin. Our findings recommend a lower cutoff value than suggested by the World Health Organization for overweight and obesity among this racial-ethnic group.

Key Words: Body mass index, Diabetes mellitus, Hyperlipidemia, Non-alcoholic fatty liver disease, Obesity, Waist-to-hip ratio

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