Table 1.
Effects of Rg1 on blood pressure
| WKY | SHR | SHR-Rg1(5) | SHR-Rg1(10) | SHR-Rg1(20) | |
|---|---|---|---|---|---|
| SBP(mmHg) |
133.7 ± 2.2 |
184.5 ± 3.4### |
186.0 ± 2.4### |
183.5 ± 3.3### |
183.0 ± 4.2### |
| DBP(mmHg) |
97.5 ± 2.0 |
139.0 ± 3.0### |
138.0 ± 2.4### |
139.1 ± 2.8### |
133.8 ± 3.9### |
| HR (bpm) |
360.6 ± 14.0 |
393.6 ± 12.5# |
366.7 ± 13.7 |
412.6 ± 8.9 |
433.5 ± 9.3* |
| MAP(mmHg) |
111.5 ± 6.3 |
170.1 ± 16.7### |
181.6 ± 14.0### |
175.4 ± 37.4### |
193.7 ± 10.4### |
| EDP(mmHg) |
6.1 ± 1.7 |
7.5 ± 3.0 |
3.1 ± 1.0 |
4.8 ± 3.9 |
5.5 ± 1.8 |
| LVSP(mmHg) |
120.9 ± 7.1 |
207.1 ± 17.9### |
213.7 ± 21.1### |
224.3 ± 35.4### |
217.5 ± 16.8### |
| +dP/dtmax (mm HgS-1) |
8661.1 ± 717.7 |
11735.7 ± 635.8## |
13063.6 ± 470.8### |
12651.9 ± 803.0## |
12636.7 ± 514.7### |
| -dP/dtmax (mm HgS-1) |
−7514.6 ± 626.0 |
−11272.1 ± 872.8## |
−12410.0 ± 595.7### |
−11330.2 ± 722.8### |
−11464.1 ± 534.8### |
| HW/BW(mg/g) | 2.9 ± 0.2 | 3.9 ± 0.05# | 3.8 ± 0.08# | 3.8 ± 0.07# | 3.6 ± 0.06# ** |
All the values are expressed as mean ± S.E. Systolic pressure (SBP), diastolic pressure (DBP), heart rate (HR), mean arterial pressure (MAP), maximum rate of pressure development for relaxation (−dP/dtmax), maximum rate of pressure development for contraction (+dP/dtmax), left ventricular systolic pressure (LVSP) were demonstrated. Heart weight divided by body weight (HW/BW) is also calculated. MAP, EDP, LVSP, +dp/dtmax, -dp/dtmax were acquired using Millar catheter and recorded by PowerLab 8/30 instrument (ADInstruments, Australia). Heart rate, SBP and DBP were acquired by tail-cuff apparatus. Mean values of data from different treatment groups were compared using one-way ANOVA. After confirming the equal variances, unpaired Student’s t-test was used to compare difference between means of two groups using SigmaPlot software. #P < 0.05, ###P < 0.001 versus WKY; **P < 0.01, ***P < 0.001 versus SHR. n = 10 for each group.