Table 2.
Gene ontology and description of significant differentially expressed genes (P < 0.05; > 2 fold change)
| Affymetrix ID1 | Genbank accession number | Fold Change2 | SD3 | P-value4 | Description5 | GO Molecular funtion6 | GO Biological process7 |
|---|---|---|---|---|---|---|---|
| Ssc.30381.1.A1_at |
CO991016 |
361.988 |
84.148 |
0.039 |
Unknown |
||
| Ssc.17891.1.A1_at |
CF175823 |
29.073 |
8.518 |
0.029 |
Unknown |
||
| Ssc.13408.1.A1_at |
BI405159 |
19.229 |
5.72 |
0.030 |
Unknown |
||
| Ssc.10537.1.A1_at |
BF711416 |
15.897 |
1.497 |
0.002 |
Unknown |
||
| Ssc.29577.1.A1_at |
CO940471 |
14.279 |
0.259 |
0.006 |
Unknown |
||
| Ssc.24631.1.S1_at |
CK461650 |
11.635 |
1.792 |
0.007 |
Formin 1 |
Protein binding |
Cell adhesion |
| Ssc.31062.1.S1_at |
AJ663560 |
8.047 |
1.593 |
0.021 |
Unknown |
||
| Ssc.28701.1.S1_at |
BG895814 |
8.008 |
0.889 |
0.015 |
Sorbin and SH3 domain isoform 2, transcript variant 14 |
Receptor activity |
Signaling pathway |
| Ssc.29538.1.A1_at |
CO941727 |
7.984 |
0.567 |
0.020 |
Unknown |
||
| Ssc.10128.1.A1_at |
BI399899 |
7.217 |
1.986 |
0.039 |
similar to H. sapiens SIX homebox 4 |
Unknown |
Unknown |
| Ssc.16289.1.A1_at |
U15437.1 |
5.927 |
1.945 |
0.047 |
Ig heavy chain variable VDJ region |
Protein binding |
Immune response |
| Ssc.16269.1.S1_at |
U15523.1 |
2.919 |
0.594 |
0.047 |
Ig heavy chain variable VDJ region |
Protein binding |
Immune response |
| Ssc.15942.5.A1_x_at |
U38202.1 |
2.571 |
0.398 |
0.044 |
|
|
|
| Ssc.17872.1.A1_at |
CF175649 |
5.731 |
1.428 |
0.047 |
COUP transcription factor 1 (COUP-TF1) |
Transcription factor |
Signaling pathway |
| Ssc.31126.1.A1_at |
CO942136 |
5.391 |
0.792 |
0.035 |
Unknown |
||
| Ssc.29622.1.A1_at |
CO942607 |
4.96 |
0.634 |
0.009 |
Unknown |
||
| Ssc.17942.1.A1_at |
CF176409 |
4.605 |
0.287 |
0.020 |
Unknown |
||
| Ssc.31069.1.A1_s_at |
BF712013 |
4.578 |
0.478 |
0.014 |
DAZ interacting protein 3, zinc finger |
Protein binding |
Ubiquitin-dependent protein catabolic process |
| Ssc.6157.1.A1_at |
BQ597772 |
3.782 |
0.555 |
0.021 |
Zinc finger protein 521 |
Unknown |
Unknown |
| Ssc.1411.1.S1_at |
BM190304 |
3.586 |
0.152 |
0.013 |
Thrombospondin 4 (TSP-4) |
Cation binding, protein binding |
Cell adhesion |
| Ssc.7524.1.A1_at |
BQ599075 |
3.397 |
0.719 |
0.033 |
Sk/Dkk-1 protein precursor |
Protein binding |
Signaling pathway |
| Ssc.8931.1.A1_at |
BI398736 |
3.336 |
0.818 |
0.037 |
Angiopoietin-like protein 2 (Angptl2) |
Unknown |
Signaling pathway |
| Ssc.13693.1.A1_at |
BQ603203 |
3.313 |
0.589 |
0.026 |
Unknown |
||
| Ssc.4707.1.A1_at |
BI118246 |
3.271 |
0.917 |
0.049 |
H. sapiens kit ligand (KITLG) |
Protein binding |
Cell adhesion |
| Ssc.13265.1.A1_at |
BQ605073 |
3.236 |
0.602 |
0.029 |
Unknown |
||
| Ssc.7967.1.A1_at |
BQ599891 |
3.153 |
0.663 |
0.033 |
Unknown |
||
| Ssc.8871.2.A1_at |
CK457442 |
2.929 |
0.711 |
0.043 |
Cyclin-dependent kinase inhibitor 1C (CDKN1C) |
Protein binding |
Signaling pathway |
| Ssc.20473.2.S1_at |
CK456061 |
2.909 |
0.139 |
0.001 |
Unknown |
||
| Ssc.20452.1.S1_at |
BX670488 |
2.890 |
0.616 |
0.035 |
Keratin associated protein 26-1 |
Protein binding |
Cell structure |
| Ssc.29030.1.S1_at |
CO988330 |
2.838 |
0.499 |
0.032 |
Unknown |
||
| Ssc.26632.1.S1_at |
CN155689 |
2.813 |
0.333 |
0.030 |
Tripartite motif protein 32 |
Protein binding |
Cell differentiation, ubiquitin-dependent protein catabolic process |
| Ssc.24221.2.A1_at |
BI181166 |
2.805 |
0.302 |
0.007 |
NADH-ubiquinone oxidoreductase |
Enzymatic activity |
Cell metabolism |
| |
|
|
|
|
18 kDa subunit |
|
|
| Ssc.428.10.S1_at |
AB087975.1 |
2.767 |
0.181 |
0.027 |
T cell receptor alpha chain (TCR-alpha) |
Receptor activity |
Immune response |
| Ssc.17790.1.S1_at |
AB087958.1 |
2.334 |
0.369 |
0.031 |
T cell receptor alpha chain (TCR-alpha) |
Receptor activity |
Immune response |
| Ssc.18884.1.A1_at |
CF365209 |
2.67 |
0.083 |
0.008 |
Unknown |
||
| Ssc.25538.1.S1_at |
BX918287 |
2.597 |
0.377 |
0.033 |
Zinc finger protein 502 |
Transcription factor |
Transcription |
| Ssc.26587.1.A1_at |
CN154795 |
2.592 |
0.334 |
0.030 |
Unknown |
||
| Ssc.20172.1.A1_at |
BX676733 |
2.547 |
0.347 |
0.027 |
Tumor endothelial marker 8 isoform 3 |
Protein binding, receptor activity |
Cell adhesion |
| Ssc.7090.1.A1_at |
NM_214233.1 |
2.465 |
0.435 |
0.026 |
Thioltransferase (GLRX1) |
Enzymatic activity |
Stress |
| Ssc.13474.1.A1_at |
BQ602423 |
2.454 |
0.405 |
0.022 |
Unknown |
||
| Ssc.8511.1.A1_at |
BF703957 |
2.449 |
0.275 |
0.009 |
Sus scrofa mRNA,clone: OVRM10011A06, expressed in ovary |
Unknown |
Unknown |
| Ssc.30148.1.A1_at |
CO987207 |
2.341 |
0.208 |
0.048 |
Rho-related BTB domain containing 3 (RHOBTB3) |
Protein binding, receptor activity |
Signaling pathway, ubiquitin-dependent protein catabolic process |
| Ssc.22336.1.S1_at |
CF793417 |
2.302 |
0.366 |
0.023 |
Homeobox protein Hox-B7 (Hox-2C) |
Transcription factor, protein binding |
Transcription |
| Ssc.1377.2.S1_at |
BI343023 |
2.264 |
0.19 |
0.016 |
Integrin alpha-8 (ITGA8) |
Cation binding, protein binding, receptor activity |
Cell differentiation, cell adhesion, signalling pathway |
| Ssc.29167.1.A1_at |
CO950916 |
2.198 |
0.272 |
0.030 |
Rho GTPase activating protein 5 |
Protein binding |
Cell adhesion |
| Ssc.13363.1.A1_at |
BI404946 |
2.188 |
0.31 |
0.038 |
Ubiquitin carboxyl-terminal hydrolase 24 |
Protein binding |
Ubiquitin-dependent protein catabolic process |
| Ssc.17370.1.A1_at |
BX665583 |
2.186 |
0.266 |
0.014 |
Adrenergic, alpha-1B-, receptor (ADRA1B) |
Protein binding, receptor activity |
Signaling pathway |
| Ssc.22210.2.S1_at |
CF788693 |
2.176 |
0.298 |
0.040 |
Unknown |
||
| Ssc.29565.1.A1_at |
CO942018 |
2.168 |
0.308 |
0.025 |
Unknown |
||
| Ssc.19407.1.A1_at |
CF359796 |
2.157 |
0.016 |
0.015 |
Unknown |
||
| Ssc.28265.1.A1_at |
CN025977 |
2.143 |
0.376 |
0.035 |
Unknown |
||
| Ssc.26179.1.S1_at |
BX922022 |
2.123 |
0.101 |
0.005 |
Midnolin (MIDN) |
Protein binding |
Transcription |
| Ssc.4848.1.S1_at |
CF789770 |
2.123 |
0.182 |
0.031 |
Calponin 3, acidic, transcript variant 1 |
Cation binding, protein binding |
Unknown |
| Ssc.20453.1.S1_at |
BX675824 |
2.092 |
0.228 |
0.012 |
Laminin receptor 1 |
Receptor activity |
Unknown |
| Ssc.14354.1.A1_at |
BQ601965 |
2.079 |
0.093 |
0.047 |
HHEX gene for hematopoietically expressed homeobox |
Transcription factor |
Cell differentiation, signaling pathway |
| Ssc.942.1.S1_at |
CK465005 |
2.061 |
0.165 |
0.012 |
Gap junction protein, alpha 1 (GJA1) |
Protein binding |
Cell adhesion, signaling pathway, immune response |
| Ssc.26933.1.S1_at |
CN163387 |
2.036 |
0.000 |
0.007 |
Interleukin 1 receptor accessory protein-like 1 (IL1RAPL1) |
Receptor activity |
Immune response |
| Ssc.30263.1.A1_at |
CO989398 |
2.033 |
0.300 |
0.039 |
Unknown |
||
| Ssc.16566.1.S1_at |
BF078197 |
2.025 |
0.271 |
0.025 |
Lactase phlorizinhydrolase |
Cation binding |
Cell metabolism |
| Ssc.9748.1.A1_at |
BI398784 |
−3.914 |
1.462 |
0.033 |
Unknown |
|
|
| Ssc.30189.1.A1_at |
CO987781 |
−4.078 |
1.800 |
0.038 |
Pig DNA sequence from clone CH242-94D11 on chromosome 7 |
Unknown |
Unknown |
| Ssc.8698.1.S1_at |
CN163671 |
−10.246 |
0.151 |
0.010 |
Cadherin 11, type 2, OB-cadherin (osteoblast) |
Cation binding, protein binding |
Cell adhesion |
| Ssc.18866.1.A1_at |
CF365015 |
−10.551 |
1.242 |
0.003 |
Unknown |
||
| Ssc.29259.1.A1_at | CO953119 | −14.935 | 2.417 | 0.048 | Zinc finger protein 567 | Transcription factor | Transcription |
1 Affymetrix ID identifies the probe based on Affymetrix accession number.
2 Fold change is the normalized average log2 ratio of infected/uninfected wild pigs (negative values denote dowregulation in infected animals).
3 SD is the standard deviation of the normalized average log2 ratio.
4 P-value determined from the average log2 ratio.
5 Description indicates a short description of the gene.
6 GO molecular function is the function of the gene according to GO entries.
7 GO biological process indicates the gene process according to GO entries.