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. 2012 Sep 24;7(9):e45904. doi: 10.1371/journal.pone.0045904

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© 2012 Huang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A and D) Shh positive placodes are decreased in Wls-deficient skin compared with the control. (B and E) Bmp4 expressing dermal condensates are reduced in K14-cre;Wls^c/c mutants. (C and F) Lef1 positive placodes decrease significantly in Wls-deficient skin. (G) Statistical analysis of the Shh, Bmp4 and Lef1 positive spots in embryo skin. **, P<0.01; *, P<0.05. cKO, K14-cre;Wls^c/c.