Figure 3. Effect of 11,12-EET on pulmonary artery pressure in lungs from wild-type (WT) and BKβ₁ ^−/− mice.

(A) 11,12-EET (10 nmol/L to 3 µmol/L)-induced increase in pulmonary arterial pressure (ΔPAP) in the absence or presence of iberiotoxin (IbTx, 300 nmol/L). (B) Effect of solvent, and 11,12-EET (3 µmol/L) on the hypoxia-induced increase in pulmonary arterial pressure (ΔPAP), in the absence and presence of IbTx. (C) Effect of U46619 (1–300 nmol/L) on pulmonary arterial pressure (ΔPAP) in lungs from WT and BKβ₁ ^−/− mice. All experiments were performed in the presence of diclofenac (10 µmol/L) and L-NA (300 µmol/L). The graphs summarize data obtained in 4–8 independent experiments; *P<0.05, **P<0.01, ***P<0.001 versus WT.