Table 2. Comparing global enrichment of hypo- vs. hyper-methylated loci in bivalent chromatin domains.

	Global Enrichment		Is overlap for hyper sites > hypo sites?
	bivalent sites (n = 1792)	P value	Fold difference	P value
Brain Adult only, hypo (n = 440) [8]	0.9055	0.752
Brain Adult only, hyper (n = 1867) [8]	3.659	0.00002	4.727	0.00004
Brain Child only, hypo (n = 154) [8]	1.326	0.2618
Brain Child only, hyper (n = 287) [8]	3.392	0.00002	2.28	0.00164
Brain Fetal only, hypo (n = 83) [8]	0.3875	0.9572
Brain Fetal only, hyper (n = 20) [8]	2.77	0.1299	4.446	0.09896
Brain Adult only, hypo (top 100) [8]	0.654	0.8946
Brain Adult only, hyper (top 100) [8]	8.085	0.00002	10.67	0.00002
Brain Child only, hypo (top 100) [8]	1.365	0.2754
Brain Child only, hyper (top 100) [8]	4.427	0.00006	2.75	0.05192
Blood Adult hypo (n = 360) [4]	2.017	0.00094
Blood Adult hyper (n = 223) [4]	6.498	0.00002	2.571	0.00002
Adult T1D, hypo (n = 278) [4]	1.365	0.1393
Adult T1D, hyper (n = 405) [4]	9.255	0.00002	4.637	0.00002