Figure 2. Scanning angle interference imaging of microtubules.
(a) Epifluorescence image (left panel) of microtubules in a fixed epithelial cell. The red box marks the region of interest (ROI) shown in the right panels; immunofluorescence (top) and the corresponding scanning angle interference image (bottom) are shown. (b) The schematic shows dual-labeled talin, which binds to integrin and actin through its FERM and THATCH domains, respectively. The images show the difference in height of the integrin-binding N-terminus of talin and the actin-binding C-terminus. Scale bars – 5 μm.