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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Cell Signal. 2012 Jan 20;24(5):981–990. doi: 10.1016/j.cellsig.2012.01.008

Fig. 2.

Fig. 2

Activation of ASK kinases in response to oxidative stress. A) Oxidation of thioredoxin (TRX) results in disulfide bond formation between Cys-32 and Cys-35 and subsequent dissociation from ASK1. ASK1 undergoes complete homo-oligomerization and subsequent autophosphorylation at Thr-838 located in the kinase domain. B) Hetero-oligomerization of ASK1 and ASK2 stabilizes ASK2, resulting in 1) the autophosphorylation of ASK2 at Thr-806, and 2) the subsequent phosphorylation of ASK1 at Thr-838 by ASK2.