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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Cell Signal. 2012 Jan 20;24(5):981–990. doi: 10.1016/j.cellsig.2012.01.008

Fig. 6.

Fig. 6

Isoforms of p66Shc, p52Shc and p46Shc. Schematic representation of three isoforms produced from the human ShcA gene (CH1 and 2, proline-rich collagen homology domain-1 and 2; CB, cytochrome c binding domain; PTB, phosphotyrosine binding domain; and SH2, Src homology 2 domain); numbers define the regions of different domains according to human p66Shc amino acid sequence; Met-111 and -156 of p66shc are equivalent to the first methionines of p52Shc and p42Shc. ROS-mediated phosphorylation sites are at Ser-36 and -54; Thr-386; pro-apoptotic residues are Cys-59 and Glu-132/133.