Table 1.

Dissociation constants (K_d, nM) of unedited NEIL1 and edited NEIL1 for 30 bp DNA duplexes^[a]

Central base pair	Unedited NEIL1	Edited NEIL1
riboFTg(5R)-A	12±3	15±4
riboFTg(5S)-A	18±1	22±6
araFTg(5S)-A	21±3	37±8
T-A	42±2	40±7
riboFTg(5R)-G	1.4±0.2	1.5±0.2
riboFTg(5S)-G	2.4±0.3	3±1
araFTg(5S)-G	2.4±0.4	2.9±0.7
T-G	7 ± 2	7 ±3

^[a]All measurements were performed at 25°C with 10 pM DNA and various amounts of enzyme. Errors reported in dissociation constants are standard deviation of the average of at least three trials. The concentrations of enzyme are active enzyme concentrations.