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. 2012 May 30;32(22):7454–7465. doi: 10.1523/JNEUROSCI.6379-11.2012

Figure 2.

Figure 2.

Knocking out caspase-6 eliminates caspase-6 expression. A, Vector scheme for caspase-6 knock-out mouse. B, Western blot of procaspase-6 protein in 15-month-old WT, Casp6+/−, and −/− cortex. The band to the right of the asterisk is nonspecific. C, Immunocytochemistry of cleaved caspase-6 in WT and Casp6−/− striatal neuronal cultures. D, Western blot of procaspase-6 and cleaved lamin C protein production in 13-month-old WT, BACHD, and BACHD Casp6−/− striatal lysates. The arrow points to cleaved lamin C, and the asterisk indicates nonspecific band. E, Western blot of procaspase-6 levels in 13-month-old WT, BACHD, and BACHD Casp6−/− cortical lysates.