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Aggregate formation is reduced in BACHD Casp6−/− striatum and cortex. A, Immunofluorescence of 13-month-old cortex and striatum using the S830 Htt aggregate antibody counterstained with DAPI. B, Quantification of aggregates shows a dramatic decrease in number in BACHD Casp6−/− (n = 3–6; ANOVA, *p < 0.05). Error bars indicate SD.
