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. Author manuscript; available in PMC: 2013 Aug 21.
Published in final edited form as: Lab Chip. 2012 Jun 22;12(16):2951–2958. doi: 10.1039/c2lc40373k

Figure 2. Amplifier circuits in paperfluidic devices.

Figure 2

(A) Schematic of the CHA amplifier. A sample strand, S, acts as a catalyst that allows two complementary hairpins (A2 and M2) to form a double-stranded product, with concomitant release of a fluorescent oligonucleotide from Fx-Qx, similar to the strand-displacement reaction shown in Figure 2. (B) Fluorescent readout of the amplifier. The amplifier executed in the context of the paperfluidic device showed three-fold higher signal than the equivalent linear system described in Figure 2. (C) Shows the a fluorescence image of the paper strip from which data was collected