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. Author manuscript; available in PMC: 2013 Aug 21.
Published in final edited form as: Lab Chip. 2012 Jun 22;12(16):2951–2958. doi: 10.1039/c2lc40373k

Figure 3. Signal immobilization in the paperfluidic device.

Figure 3

(A) Schematic of the reaction. Released fluorescent oligonucleotides can be captured at specific sites within the paperfluidic device, via beads containing antisense oligonucleotides. (B) Micrographs of immobilized beads. Beads caught in the paper fibers (fluorescence micrograph, top, brightfield, bottom) capture fluorescent oligonucleotide. (C) Schematic of paperfluidic device for detection by oligonucleotide capture on beads. A detection region (Beads X-Xb) is embedded into the paper just downstream of the DNA reagents. (D) Fluorescence image of successful capture showing residual, unreacted F-Fb downstream of bead spots.