Table 2.
Publications on Cholangiocarcinoma and PET
| Cholangiocarcinoma | ||||
|---|---|---|---|---|
| Author | Year | N | Results | Conclusion |
| Kluge | 2001 | 26 | Sensitivity and specificity of 92% and 93% in identifying CCA | Suitable for detection of CCA |
| Anderson | 2004 | 36 | Overall sensitivity of 61% for detecting CCA; 85% for nodular-type and 18% for infiltrating-type CCA | PET may not be able to differentiate various histological types of CCA |
| Petrowsky | 2006 | 47 | Sensitivity for intrahepatic and extrahepatic CCA were 93% and 55% compared to 78% and 58% for CT | PET superior to CT for intrahepatic CCA but not for extrahepatic CCA |
| Corvera | 2007 | 62 | Sensitivity of 78% and specificity of 75% for all CCA types; sensitivity differed between intrahepatic and extrahepatic CCA (95% vs 69%) | High rate of detecting CCA but overall more sensitive for intrahepatic than extrahepatic CCA |
| Kim | 2008 | 123 | Sensitivity of 95% and 81% for intrahepatic and extrahepatic CCA compared to CT (95%, 81%) and MRI (100%, 95%) | Comparable to CT but inferior to MRI in detecting CCA |
| Moon | 2008 | 54 | Sensitivity of 91% for intrahepatic CCA and 83% for perihilar CCA compared to CT (87% and 92%) | May be useful as a complementary tool to CT for detecting CCA |
| Metastasis | ||||
| Kluge | 2001 | 26 | Identified 7 out of 10 patients with distant metastases but only 2 out of 15 patients with known regional nodes | Suitable for detecting distant metastases but not regional lymph nodes |
| Petrowsky | 2006 | 47 | Detected 2 out of 17 regional metastases but 12 out of 12 distant metastases | PET not suitable for detection of regional lymph nodes but valuable for distant metastases |
| Corvera | 2007 | 62 | Overall sensitivity of 95% in detecting nodal and distant metastases, resulting in change of treatment in 25% of patients | Good for detecting both regional and distant metastases |
| Kim | 2008 | 123 | Distant metastasis detection rate of 58% compared to 0% for CT | Valuable for detecting distant metastases |
| Moon | 2008 | 54 | Detected 24 out of 24 metastatic foci in 19 patients in addition to 9 metastatic lesions not previously seen on CT | Good for detecting distant metastases |
| Differentiation | ||||
| Moon | 2008 | 54 | Showed significant difference in SUVmax and SUV ratio between benign and malignant lesions. Perihilar CCA had significantly lower values compared to intrahepatic and extrahepatic CCA | Shows promise in differentiating benign from malignant disease |
CCA: Cholangiocarcinoma; PET: Positron emission tomography; US: Ultrasound; CT: Computed tomography; MRI: Magnetic resonance imaging; RFA: Radio frequency ablation; FDG: Fluorine-18-fluorodeoxyglucose; SUV: Standardized uptake value; Sens: Sensitivity; Spec: Specificity