Table 1.

Structures and IC₅₀ values of the (β-lactam-based PSA inibitors developed by Adlington et al. (1997, 2001).

Compound	R1	R2	R3	IC50 (μM)
1	H	CO2Bn	CO2H	8.98 ± 0.1
2	H	P-CO2CH2-C6H4-CO2H	CO2H	5.84 ± 0.9
3	H	H	CO2H	24.3 ± 3.9
4	H	CO2H	CH2NH2-TFA	1.34 ± 0.1
5	H	CO2Bn	H	1.43 ± 0.2
6a	OH	CO2Bn	H	0.348 ± 0.1
7b	OH	CO2Bn	H	0.226 ± 0.01

^aRacemic mixture of compounds.

^bHomochiral 3S4S enantiomer.