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. Author manuscript; available in PMC: 2012 Sep 24.
Published in final edited form as: Biol Chem. 2010 Apr;391(4):333–343. doi: 10.1515/BC.2010.044

Table 2.

The chemical structures, Ki values and GOLD scores of the PSA inhibitors used in this study.

graphic file with name nihms336643u2.jpg
Compound R Ki(μM) GOLD Score (PSA)
8 CH2CH2CONH2 45.21 ± 3.89 33.45
9 CH2CH2CON(CH3)2 2.53 ± 0.13 30.66
10 CH2CON(CH3)2 13.09 ± 0.88 19.82
11 CH2NHCHO 0.91 ± 0.06 29.54
12 CH2NHCOCH3 3.91 ± 0.35 29.56
13 CH2NHCOCH2CH3 9.84 ± 0.33 34.13
14 CH2NHCOCH(CH3)2 13.28 ± 0.93 33.25
15 CH2NHCO(C6H5) >25 27.55
16 CH2CH2SCH3 3.84 ± 0.21 34.77
17 CH2CH2SOCH3 7.25 ± 0.44 38.27
18 CH2CH2CN 8.14 ± 0.29 27.47
19 CH(CH3)2 >100 16.16
20 CH2CH(CH3)2 6.51 ± 0.25 26.37
21 CH2CH2CH2CH3 11.24 ± 0.26 30.93
22 (C6H5) >100 22.92
23 CH2(C6H5) 0.57 ± 0.04 38.84
24 CH2(C6H5)OH 0.37 ± 0.02 39.66