. Author manuscript; available in PMC: 2012 Sep 24.

Published in final edited form as: Biol Chem. 2010 Apr;391(4):333–343. doi: 10.1515/BC.2010.044

Table 3.

The specificity of six peptides aldehydes for PSA versus chymotrypsin and the corresponding GOLD scores for each protease.

Compound	PSA	Chymotrypsin	Chy/PSA ratio^b	PSA	Chymotrypsin
	K_i (μM)^a	K_i (μM)^a		Gold score	Gold score
8	45.21 ± 3.89	>1000	>22	33.45	16.53
9	2.53 ± 0.13	>100	>40	30.66	14.27
11	0.91 ± 0.06	>100	> 110	29.54	19.25
16	3.84 ± 0.21	>100	>26	34.77	23.07
23	0.57 ± 0.04	0.62 ± 0.05	1.08	38.84	28.38
24	0.37 ± 0.02	0.29 ± 0.03	0.78	39.66	28.86

Value reported is for n=3 (±S.E.).

PSA selectivity in terms of (Chymotrypsin K_i/(PSA K_i).