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. Author manuscript; available in PMC: 2012 Sep 24.
Published in final edited form as: Gastroenterology. 2009 May 18;137(3):965–97610. doi: 10.1053/j.gastro.2009.05.043

Figure 4. Dramatic effects of DSS in NHE3-deficient mice.

Figure 4

(A) Mortality of NHE3+/+, NHE3+/−, and NHE3−/− mice in response to DSS. Red dashed line represents mortality rates in NHE3−/− mice treated with 4% DSS and ciprofloxacin and metronidazole. Table depicts body weight loss in WT and NHE3−/− mice treated with 4% DSS with or without antibiotics. Gross intestinal morphology in WT (B) and NHE3−/− mice (C) treated with 4% DSS for 48 hrs. Visible thickening of the colonic wall and intestinal hemorrhage extending into the proximal small intestine in NHE3−/− mice.