Table 3.

Results of the analysis of using the 3LTP Catalytic Atom Map to search the PDB90 data set. Data is shown for matches to the CAM with a GeometryScore ≤ 0.7 Å and an ActiveSiteScore > 0, except where noted.

PDB	Protein	RMSD (Å)	Avg. WCN z-scorea	Metal within 2.5 Å?	Catalytic Element Identified
2FDS	Orotidine 5′-monophosphate decarboxylase	0.42	1.58	No	?
3HJZb	Transaldolase	0.48	0.53	No	One lysine functions as a nucleophile; reaction proceed through a Schiff base intermediate
2PS2	Mandelate racemase	0.48	1.09	Yes	Carboxylate residues bind Mg2+, lysines function as general acid/base
2CZD	Orotidine 5′-monophosphate decarboxylase	0.54	1.70	No	?
2HXT	L-fuconate dehydratase	0.61	1.39	Yes	Carboxylate residues bind Mg2+, lysines function as general acid/base
3H12	Mandelate racemase	0.64	0.94	Yes	Carboxylate residues bind Mg2+, lysines function as general acid/base
2A4A	Deoxyribose phosphate aldolase	0.65	1.42	No	One lysine functions as a nucleophile; reaction proceed through a Schiff base intermediate
2ZAD	Muconate cycloisomerase	0.65	1.63	Yes	Carboxylate residues bind Mg2+, lysines function as general acid/base
1N7K	Deoxyribose phosphate aldolase	0.69	1.13	No	One lysine functions as a nucleophile; reaction proceed through a Schiff base intermediate

^aWCN z-score is the average of the WCN z-scores for each of the residues identified by the Catalytic Atom Map.

^b3HJZ was the aldolase structure with the lowest RMSD identified, but its ActiveSiteScore was 0, as it had not been annotated in the Catalytic Site Atlas at the time of this analysis.