Table 4. Early and sustained induction of TLO associated genes in allografts from latently infected donors.
Shown are fold change values compared to uninfected non-transplanted hearts (n=3 for each time point).
Latently Infected Donor (LDI) |
Uninfected Control |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
POD | 7 | 14 | 21 | 28 | 35 | 7 | 14 | 21 | 28 | 35 |
|
|
|||||||||
CCL19 | 4.5* | 6.6 | 14.8 | 17.4 | 11.8 | 1.6 | 2.7 | 7.8 | 10.2 | 7.8 |
CCL21 | 1.4 | 2.1 | 3.1* | 2.2* | 1.0 | 1.2 | 1.4 | 1.1 | 0.7 | 0.8 |
CXCL13 | 9.0* | 10.0 | 11.9 | 13.2 | 13.8 | 3.2 | 7.1 | 4.9 | 9.8 | 11.8 |
|
|
|||||||||
ICAM-1 | 3.9* | 3.7 | 4.5 | 5.9 | 5.2 | 1.3 | 3.1 | 2.7 | 3.1 | 5.6 |
MADCAM1 | 1.1* | 2.0 | 1.3 | 3.0 | 1.7 | 0.8 | 1.2 | 0.8 | 0.9 | 0.9 |
VCAM-1 | 3.6* | 4.9 | 6.0 | 7.7 | 7.7 | 1.7 | 4.4 | 3.2 | 5.0 | 6.8 |
|
|
|||||||||
Lymphotoxin A | 0.7 | 0.6 | 1.0 | 1.2 | 0.9 | 0.6 | 0.5 | 0.7 | 0.9 | 0.9 |
Lymphotoxin B | 4.5* | 3.8* | 6.4 | 10.7* | 11.4 | 2.0 | 2.2 | 3.1 | 6.4 | 12.2 |
{p<0.05 infected vs. uninfected}