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. Author manuscript; available in PMC: 2012 Sep 24.

Published in final edited form as: Circ Res. 1989 Oct;65(4):997–1020. doi: 10.1161/01.res.65.4.997

Graphs showing effects of axial diffusion (D or D_x) on the shape of outflow dilution curve [h(t)], instantaneous extraction [E(t)], and fractional escape rate [η(t)]. Upper panel: Curves for intravascular reference tracer (h_R), test diffusible solute (h_D), and E(t) at different ratios of intraplasma diffusion coefficients. Lower panel: Fractional escape rates η(t) = h(t)/R(t) for the permeating tracer at different diffusion coefficients. All permeability–surface area products are 1.0 (ml/g)/min.

Graphs showing effects of axial diffusion (D or D_x) on the shape of outflow dilution curve [h(t)], instantaneous extraction [E(t)], and fractional escape rate [η(t)]. Upper panel: Curves for intravascular reference tracer (h_R), test diffusible solute (h_D), and E(t) at different ratios of intraplasma diffusion coefficients. Lower panel: Fractional escape rates η(t) = h(t)/R(t) for the permeating tracer at different diffusion coefficients. All permeability–surface area products are 1.0 (ml/g)/min.