Figure 13.

Graph showing palmitate uptake in the isolated rabbit heart. Outflow dilution curves [h(t)s] for albumin, sucrose, and [¹⁴C]palmitate were obtained with Krebs-Ringer perfusate containing 0.4 mM albumin and 0.4 mM total palmitate at F_p = 1.6 (ml/g)/min. Model-to-data coefficients of variation were 9.5% for albumin curve, 6.4% for sucrose, and 7.3% for adenosine. Flow heterogeneity was accounted for by five paths with a relative dispersion of 50%. ${\mathrm{V}}_{\text{isf}}^{\prime }=0.36\text{ml}/\mathrm{g}$ for sucrose. The cleft PS_g was 1.31 (ml/g)/min for sucrose and 0 for palmitate. Other palmitate parameters were PS_ecl = 1.02, PS_eca = 1.4, G_ec = 0, PS_pc = 2.7, and G_pc = 8.1 (ml/g)/min and ${\mathrm{V}}_{\text{pc}}^{\prime }=4.3$, V_p = 0.04, and ${\mathrm{V}}_{\text{ec}}^{\prime }=0.02\text{ml}/\mathrm{g}$ (G. van der Vusse and S. Little, unpublished data). (For definition of terms, refer to Figure 1.)