Abstract
Apolipoprotein L1 in plasma is associated with high-density lipoprotein. Novel APOL1 polymorphisms are investigated along with the association of two common haplotypes (Lysl66Glu, Ile244Met, Lys271Arg) with circulating lipid and glucose levels. Although the amino acid substitutions occur in the amphipathic alpha helices region involved in lipid binding, these substitutions were found not to independently account for variability in circulating lipid and glucose levels in 149 middle age males.
Key Words: Apolipoprotein L, Blood Lipids, Glucose, Polymorphisms
Full Text
The Full Text of this article is available as a PDF (66.4 KB).
References
- Duchateau P.N., Pullinger C.R., Orellana R.E., Kunitake S.T., Naya-Vigne J., O’Connor P.M., Malloy M.J., Kane J.P. Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. Journal of Biological Chemistry. 1997;272:25576–25582. doi: 10.1074/jbc.272.41.25576. [DOI] [PubMed] [Google Scholar]
- Duchateau P.N., Movsesyan I., Yamashita S., Sakai N., Hirano K., Schoenhaus S.A., O’Connor-Kearns P.M., Spencer S.J., Jaffe R.B., Redberg R.F., Ishida B.Y., Matsuzawa Y., Kane J.P., Malloy M.J. Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidaemic, hyperlipidaemic, and diabetic subjects. journal of Lipid Research. 2000;41:1231–1236. [PubMed] [Google Scholar]
- Duchateau PN, Pullinger C.R, Cho M.H, Eng C., Kane J.P. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. Journal of Lipid Research. 2001;42:620–630. [PubMed] [Google Scholar]
- Friedewald W.T., Levy R.I. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry. 1972;18:499–502. [PubMed] [Google Scholar]
- Monajemi H., Fontijn R.D., Pannekoek H., Horrevoets A.J. The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. Genomics. 2002;79:539–546. doi: 10.1006/geno.2002.6729. [DOI] [PubMed] [Google Scholar]
- Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J. The human apolipoprotein L gene cluster: identification, classification and sites of distribution. Genomics. 2001;74:71–78. doi: 10.1006/geno.2001.6534. [DOI] [PubMed] [Google Scholar]
- Rye K.A., Clay M.A., Barter B.J. Remodelling of high density lipoproteins by plasma factors. Atherosclerosis. 1999;145:227–238. doi: 10.1016/S0021-9150(99)00150-1. [DOI] [PubMed] [Google Scholar]