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. 2012 Jul 30;30(28):3452–3459. doi: 10.1200/JCO.2011.41.0985

Fig 3.

Fig 3.

Overall (OS) and progression-free survival (PFS) of patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone according to presence of concurrent expression of MYC and BCL2 proteins (MYC+/BCL2+) and/or presence of concurrent MYC and BCL2 translocations. Kaplan-Meier curves represent OS according to presence of MYC+/BCL2+ in (A) the training cohort (n = 164) and (B) validation cohort (n = 140). (C) Both training and validation cohorts were combined because of the low frequency of double hits (DHITs). Patients were stratified according to presence of DHIT or MYC+/BCL2+ excluding DHITs. Four DHIT patient cases had no MYC protein expression; one had a missing value for BCL2 protein expression.