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. 2012 Oct;192(2):385–396. doi: 10.1534/genetics.112.142802

Figure 5 .

Figure 5 

Frequent NF1 deletion in human breast cancer. (A) Percentage of NF1 CNA and mutation in 511 human breast tumors, including 57 Her2-Enriched and 93 Basal breast tumors (publically available TCGA data). Note that 27.7% of human breast tumors have NF1 deletion or mutation, and HER2-enriched and basal breast tumor subtypes have ≥40% NF1 deletion or mutation. (B) Boxplot of NF1 mRNA expression vs. copy number in human breast cancer. Data are from TCGA Research Network. P-value is for ANOVA between het-loss and diploid groups, indicating expression levels significantly correlate with genomic deletion status.