Table 2 . Cancer and immunity-related genes in Chaos3 mammary tumor CNAs.
| Amplified |
Deleted |
|||||||
|---|---|---|---|---|---|---|---|---|
| Function | Chr 16 | Chr 12 | Function | Chr 4 | Chr 5 | Chr 11 | Chr 10 | Chr 19 |
| Pluripotency | Dppa4, Dppa2 | Tumor suppressor | Cdk2ap1 | Nf1* | ||||
| Signal transduction | Adam6* | DNA checkpoint/repair | Kntc1, Gtf2h3, Setd8 | Rad9 | ||||
| Immunity/inflammation | Pvrl3, Retnlb, Retnla | Ig/abparts* | Apoptosis/necrosis | Dffa, Ube4b*Kif1b* | Oaz1* | |||
| Upregulated in cancer | Igsf11 | Signal transduction | Pik3cd | Ksr1* | Csnk1g2* Mknk2* | |||
| Immunity/inflammation | Lingo3* | |||||||
| Cancer related | Arid1a, Sfn* | Sbno1 | Minpp1* | |||||
The genes commonly altered specifically in mammary tumors are underlined, and those that additionally have CNAs in human breast cancers are marked with an asterisk. Ig/abparts, Ig locus and antibody parts gene feature conserved between mice and humans.