Normal Responders

Higher starting doses in normal responders lead to more oocytes, butonly in young patients.

Clinical pregnancy rates do not improve when higher doses are administered (100 vs. 200 IU or 150 vs. 250 IU).

The majority of RCTs fail to show that the retrieval of more oocytes translates in the availability of more frozen embryos.

In their first cycle most patients should respond well to 150–200 IU/day. Whether special allowances need to be made for BMI, PCOS, age or other factors is unclear.

Poor Responders

Increasing the dose of FSH during a cycle is not effective in averting a poor response.

There is insufficient evidence for an increased FSH dose after a previous poor response.

Although not supported by good evidence most authors seem to be comfortable with a starting dose of 300 IU/day. Similarly, a maximum dose of 450 IU/day seems to be universally accepted.