Table 2.
The odds ratio of Ala119Ser, Leu432Val, Asp449(C>T), Asn453Ser polymorphisms of the CYP1B1 genotypes
| CYP1B1 | Number (%) | Adj OR (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| polymorphism | Genotype/allele | Control | Endometriosis | OR (95% CI) | p-value | Age, BMI | p-value |
| Ala119Ser | Ala/Ala | 113 (60.1) | 146 (66.1) | 1 | – | 1 | – |
| Ala/Ser | 68 (36.2) | 69 (31.2) | 0.785 (0.518–1.190) | 0.254 | 0.760 (0.497–1.162) | 0.206 | |
| Ser/Ser | 7 (3.7) | 6 (2.7) | 0.663 (0.217–2.029) | 0.472 | 0.630 (0.203–1.949) | 0.422 | |
| Ala/Ser+Ser/Ser | 75 (39.9) | 75 (33.9) | 0.774 (0.517–1.159) | 0.213 | 0.748 (0.495–1.131) | 0.169 | |
| Ala allele | 294 (78.2) | 361 (81.7) | 1 | – | 1 | – | |
| Ser allele | 82 (21.8) | 81 (18.3) | 0.804 (0.571–1.134) | 0.214 | 0.784 (0.553–1.112) | 0.172 | |
| Leu432Val | Leu/Leu | 160 (85.1) | 178 (80.5) | 1 | 1 | ||
| Leu/Val | 25 (13.3) | 41 (18.6) | 1.474 (0.858–2.533) | 0.160 | 1.447 (0.839–2.497) | 0.184 | |
| Val/Val | 3 (1.6) | 2 (0.9) | 0.599 (0.099–3.632) | 0.578 | 0.571 (0.094–3.468) | 0.542 | |
| Leu/Val+Val/Val | 28 (14.9) | 43 (19.5) | 1.380 (0.819–2.326) | 0.226 | 1.352 (0.799–2.286) | 0.261 | |
| Leu allele | 345 (91.8) | 397 (89.8) | 1 | – | 1 | ||
| Val allele | 31 (8.2) | 45 (10.2) | 1.261 (0.781–2.038) | 0.292 | 1.233 (0.761–1.998) | 0.394 | |
| Asp449(C>T) | CC | 161 (85.6) | 181 (81.9) | 1 | – | 1 | – |
| TC | 24 (12.8) | 38 (17.2) | 1.408 (0.810–2.449) | 0.225 | 1.400 (0.810–2.449) | 0.225 | |
| TT | 3 (1.6) | 2 (0.9) | 0.593 (0.098–3.594) | 0.570 | 0.565 (0.093–3.435) | 0.536 | |
| TC+TT | 27 (14.4) | 41 (18.1) | 1.318 (0.774–2.244) | 0.310 | 1.305 (0.763–2.231) | 0.330 | |
| C allele | 346 (92.0) | 400 (90.5) | 1 | 1 | |||
| T allele | 30 (8.0) | 42 (9.5) | 1.211 (0.742–1.977) | 0.444 | 1.195 (0.730–1.957) | 0.478a | |
| Asn453Ser | Asn/Asn | 185 (98.4) | 217 (98.2) | 1 | – | 1 | – |
| Asn/Ser | 3 (1.6) | 4 (1.8) | 1.137 (0.251–5.144) | 0.868 | 1 | ||
| Ser/Ser | 0 (0.0) | 0 (0.0) | NA | NA | 1.137 (0.251–5.144) | 0.868 | |
| Asn allele | 370 (98.4) | 434 (98.2) | 1 | 1 | |||
| Ser allele | 6 (1.6) | 8 (1.8) | 1.137 (0.391–3.306) | 0.814 | 1.137 (0.391–3.306) | 0.814 | |