Table 3.
Frequencies of diplotype and haplotype with the risk of emdometriosis among Ala119Ser, Leu432Val, Asp449(C>T) and Asn453Ser polymorphisms of the CYP1B1 genotype
| Number (%) | Adj OR (95% CI) | |||||
|---|---|---|---|---|---|---|
| Control | Endometriosis | OR (95% CI) | p-value | Age, BMI | p-value | |
| Diplotype 355G>T,4326C>G, 4379C>T,4390A>G | ||||||
| GCCA/GCCA-00 | 88 (47.1) | 107 (48.9) | 1 | – | – | – |
| GCCA/GGCA-02 | 0 (0) | 2 (0.9) | NA | 0.999 | NA | 0.999 |
| GCCA/GGTA-03 | 12 (6.4) | 26 (11.9) | 1.782 (0.850–3.734) | 0.126 | 1.789 (0.849–3.770) | 0.126 |
| GCCA/TCCA-04 | 51 (27.3) | 54 (24.7) | 0.871 (0.541–1.401) | 0.568 | 0.852 (0.524–1.387) | 0.520 |
| GCCA/GCCG-06 | 15 (8.0) | 10 (4.6) | 0.658 (0.293–1.479) | 0.311 | 0.519 (0.220–1.225) | 0.134 |
| GTTA/GGTA-13 | 2 (1.1) | 2 (0.9) | 0.822 (0.114–5.958) | 0.847 | 0.767 (0.105–5.589) | 0.794 |
| GGCA/TTCA-24 | 1 (0.5) | 1 (0.5) | 0.822 (0.051—13.338) | 0.891 | 0.672 (0.041–10.994) | 0.781 |
| GGTA/TTCA-34 | 10 (5.3) | 11 (5.0) | 0.905 (0.367–2.229) | 0.828 | 0.885 (0.357–2.190) | 0.791 |
| TTCA/TTCA-44 | 6 (3.2) | 6 (2.7) | 0.822 (0.256–2.640) | 0.742 | 0.803 (0.247–2.60) | 0.715 |
| TTCA/TGTA-45 | 1 (0.5) | 0 (0) | NA | 1.000 | NA | 1.000 |
| GCCG/TCCA-64 | 1 (0.5) | 0 (0) | NA | 1.000 | NA | 1.000 |
| Haplotype 355G>T,4326C>G, 4379C>T,4390A>G | ||||||
| GCCA-0000 | 254 (67.9) | 306 (69.9) | 1 | – | – | – |
| GCTA-0010 | 2 (0.5) | 2 (0.5) | 0.830 (0.116–5.934) | 0.853 | 0.782 (0.109–5.607) | 0.807 |
| GGCA-0100 | 1 (0.3) | 3 (0.7) | 2.490 (0.257–24.086) | 0.431 | 2.046 (0.210–19.903) | 0.537 |
| GGTA-0110 | 24 (6.4) | 39 (8.9) | 1.349 (0.790–2.303) | 0.273 | 1.343 (0.784–2.301) | 0.282 |
| TCCA-1000 | 76 (20.3) | 78 (17.8) | 0.852 (0.596–1.217) | 0.379 | 0.837 (0.582–1.205) | 0.339 |
| TGTA-1110 | 1 (0.3) | 0 (0) | NA | 1.000 | NA | 1.000 |
| GCCG-0001 | 16 (4.3) | 10 (2.6) | 0.519 (0.231–1.163) | 0.111 | 0.499 (0.221–1.127) | 0.095 |
Note. p-value (K2) = 0.000 for diplotype; p-value (K2) = 0.401 for haplotype.