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Experimental protocol. Androgen therapy with the non-aromatizable androgen DHT was administered for the final 6 weeks of study in both paradigms. A. In prevention-HT, ORX was performed at 5 months of age and treatment initiated immediately. B. In the therapeutic-LT studies, ORX was performed at 3 months of age and treatment delayed for 2 months to allow a period of hypogonadal bone loss. Analysis in both groups was performed on 6½ month old mice.
