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. Author manuscript; available in PMC: 2013 Sep 28.
Published in final edited form as: J Control Release. 2012 Aug 14;162(3):606–611. doi: 10.1016/j.jconrel.2012.08.008

Figure 5.

Figure 5

Photomicrograph of representative H&E (top) and CD8+ (bottom) micrographs demonstrate infiltration of mononuclear cell changes in plasmid, targeting polymer and polyplex treated NOD mice compared with normal (BALB/c) mice. Normal mice (BALB/c) showed no observed mononuclear cell infiltration (A, E), whereas in plasmid (B, F) and targeting polymer treated (C, G) 18-week-old female non-obese diabetic mice showed mild to severe mononuclear cell and CD8+ T-cell infiltration in and around the islets. In contrast, polyplex treated animals (D, H) showed limited peri-islet mononuclear cell and CD8+ T-cell infiltration in significantly fewer numbers of islets. Scale bar indicates 100 um.