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PolyMorphine provided extended analgesia in mice. (A) TFL test results at 0.5–24 h post-administration. (B) TFL results from day 1 through day 14 (vertical arrows indicate the days that animals received acute morphine challenge to evaluate morphine tolerance development). PolyMorphine provides extended analgesia compared with free morphine. Data are shown as mean ± standard error of mean. N = 30 for each time point prior to and including day 3. N = 15 after day 3.
