Table I.
Randomized Controlled Trials of IVIG in IVF Failure and Occult Loss Patients
| IVIG given | ||||||||
|---|---|---|---|---|---|---|---|---|
| No. of | Abnormal | No. of embryos | Clinical | Number of live | ||||
| Author | Group | patients | Prea | Post | immunity | transferred | pregnancy | births [abortions] |
| De Placido | IVIG | 18 | Yes | Yes | nd | 45 | 6 | 5b [1] |
| Placebo | 21 | nd | 61 | 4(5)c | 2b [2] | |||
| Sher | IVIG + HA | 45 | Yes | Yes | 45d | 203 | 27e | 23 [4] |
| HA | 37 | 37 | 144 | 14e | 10 [4] | |||
| Stephenson | IVIG | 26 | Yes | No | 14f | 77 | 5 | 4 [1] |
| Placebo | 25 | 15 | 68 | 7 | 3 [4] | |||
aPre- or post-ovulation.bCalculated by subtracting number of spontaneous abortions [ ] from number of clinical pregnancies.cOne patient had twins.d100% had anti-thyroid antibodies.eCalculated by adding number of abortions to number of live births.fPositive ANA or APL (by ACA or lupus anticoagulant tests).