Table II.
Effect of Pre-Conceptional IVIG in IVF Failure Patients Positive for Elevated NK Levels ± Autoantibodies
| IVIG (N = 95)a | Control (N = 22)b | |
|---|---|---|
| Average age | 35.1 | 36.8 |
| Number of IVF failures | 8 | 2 |
| Number of embryos transferred | 3.2 | 2.8 |
| Number of clinical pregnancies | 43 (47%) | 1 (4%) |
| Number of multiple pregnancies | 20 | 0 |
| Number ongoing pregnancies | 36 (37%) | 1 (4%) |
| One or more live births/number of patients | 36/95 (37%) | 1/22 (4%) |
| Number of “take-home babies”/number of embryos transfered | 54/304 (18%) | 1/62 (2%) |
| Take-home babies per patient | 54/95 (57%) | 1/62 (2%) |
aPatients with one or more elevated peripheral blood NK levels ± abnormal autoantibodytest received 0.4 g/kg Gammagard IV prior to oocyte retrieval, and every 4 weeks untilterm, if pregnant.bPatients declined IVIG due to safety or cost concerns.